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A substrate selected by phage display exhibits enhanced side-chain hydrogen bonding to HIV-1 protease

Crystal structures of inactive variants of HIV-1 protease bound to peptides have revealed how the enzyme recognizes its endogenous substrates. The best of the known substrates is, however, a nonnatural substrate that was identified by directed evolution. The crystal structure of the complex between...

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Bibliografske podrobnosti
izdano v:Acta Crystallogr D Struct Biol
Main Authors: Windsor, Ian W., Raines, Ronald T.
Format: Artigo
Jezik:Inglês
Izdano: International Union of Crystallography 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6038388/
https://ncbi.nlm.nih.gov/pubmed/29968678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798318006691
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