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Recombinant thrombomodulin ameliorates experimental autoimmune encephalomyelitis by suppressing high mobility group box 1 and inflammatory cytokines

Recombinant thrombomodulin (rTM) has pleiotrophic properties, including anti‐coagulation and anti‐inflammation; however, its effectiveness as a treatment for multiple sclerosis (MS) has not been evaluated fully. High mobility group box 1 (HMGB1) and proinflammatory cytokines, working as inflammatory...

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Bibliografiske detaljer
Udgivet i:Clin Exp Immunol
Main Authors: Uzawa, A., Mori, M., Masuda, H., Ohtani, R., Uchida, T., Kuwabara, S.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037993/
https://ncbi.nlm.nih.gov/pubmed/29509323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.13123
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