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High Tidal Volume Induces Mitochondria Damage and Releases Mitochondrial DNA to Aggravate the Ventilator-Induced Lung Injury

OBJECTIVE: This study aimed to determine whether high tidal volume (HTV) induce mitochondria damage and mitophagy, contributing to the release of mitochondrial DNA (mtDNA). Another aim of the present study was to investigate the role and mechanism of mtDNA in ventilator-induced lung injury (VILI) in...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Lin, Jin-Yuan, Jing, Ren, Lin, Fei, Ge, Wan-yun, Dai, Hui-jun, Pan, Linghui
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037891/
https://ncbi.nlm.nih.gov/pubmed/30018615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01477
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