High Tidal Volume Induces Mitochondria Damage and Releases Mitochondrial DNA to Aggravate the Ventilator-Induced Lung Injury

OBJECTIVE: This study aimed to determine whether high tidal volume (HTV) induce mitochondria damage and mitophagy, contributing to the release of mitochondrial DNA (mtDNA). Another aim of the present study was to investigate the role and mechanism of mtDNA in ventilator-induced lung injury (VILI) in...

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Foilsithe in:Front Immunol
Main Authors: Lin, Jin-Yuan, Jing, Ren, Lin, Fei, Ge, Wan-yun, Dai, Hui-jun, Pan, Linghui
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2018
Ábhair:
Immunology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037891/
https://ncbi.nlm.nih.gov/pubmed/30018615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01477
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