ISO, via Upregulating MiR-137 Transcription, Inhibits GSK3β-HSP70-MMP-2 Axis, Resulting in Attenuating Urothelial Cancer Invasion

Our most recent studies demonstrate that miR-137 is downregulated in human bladder cancer (BC) tissues, while treatment of human BC cells with isorhapontigenin (ISO) elevates miR-137 abundance. Since ISO showed a strong inhibition of invasive BC formation in the N-butyl-N-(4-hydroxybutyl) nitrosamin...

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Bibliografiske detaljer
Udgivet i:Mol Ther Nucleic Acids
Main Authors: Guo, Xirui, Huang, Haishan, Jin, Honglei, Xu, Jiheng, Risal, Sanjiv, Li, Jingxia, Li, Xin, Yan, Huiying, Zeng, Xingruo, Xue, Lei, Chen, Changyan, Huang, Chuanshu
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037888/
https://ncbi.nlm.nih.gov/pubmed/30195772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.05.017
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