Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1β Activity Reduces Pathology During Early Group A Streptococcal Skin Infection

The bacterial pathogen Group A Streptococcus (GAS) has been shown to induce a variety of human diseases ranging in severity from pharyngitis to toxic shock syndrome and necrotizing fasciitis. GAS produces a powerful peptide toxin known as Streptolysin S (SLS). Though long recognized as a potent cyto...

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Detalhes bibliográficos
Publicado no:Front Cell Infect Microbiol
Main Authors: Flaherty, Rebecca A., Donahue, Deborah L., Carothers, Katelyn E., Ross, Jessica N., Ploplis, Victoria A., Castellino, Francis J., Lee, Shaun W.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Cellular and Infection Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037840/
https://ncbi.nlm.nih.gov/pubmed/30018884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2018.00211
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