Downregulation of miR-130a, antagonized doxorubicin-induced cardiotoxicity via increasing the PPARγ expression in mESCs-derived cardiac cells

Doxorubicin (Dox) is a widely used powerful chemotherapeutic component for cancer treatment. However, its clinical application has been hampered due to doxorubicin-induced cardiomyopathy upon the cessation of chemotherapy. Previous studies revealed that PPARγ plays a crucial protective role in cardi...

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Publicado en:Cell Death Dis
Autores principales: Pakravan, Golnaz, Foroughmand, Ali Mohammad, Peymani, Maryam, Ghaedi, Kamran, Hashemi, Motahare-Sadat, Hajjari, Mohammadreza, Nasr-Esfahani, Mohammad Hossein
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037713/
https://ncbi.nlm.nih.gov/pubmed/29988029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0797-1
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