Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication

Cancer has an impressive ability to evolve multiple processes to evade therapies. While immunotherapies and vaccines have shown great promise, particularly in certain solid tumors such as prostate cancer, they have been met with resistance from tumors that use a multitude of mechanisms of immunosupp...

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Vydáno v:Mol Ther
Hlavní autoři: Kloss, Christopher C., Lee, Jihyun, Zhang, Aaron, Chen, Fang, Melenhorst, Jan Joseph, Lacey, Simon F., Maus, Marcela V., Fraietta, Joseph A., Zhao, Yangbing, June, Carl H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2018
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037129/
https://ncbi.nlm.nih.gov/pubmed/29807781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.05.003
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