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Mild and selective reduction of aldehydes utilising sodium dithionite under flow conditions
We recently reported a novel hybrid batch–flow synthesis of the antipsychotic drug clozapine in which the reduction of a nitroaryl group is described under flow conditions using sodium dithionite. We now report the expansion of this method to include the reduction of aldehydes. The method developed...
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| Published in: | Beilstein J Org Chem |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Beilstein-Institut
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6036987/ https://ncbi.nlm.nih.gov/pubmed/30013679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.14.129 |
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