Epigenetic regulation of ID4 in the determination of the BRCAness phenotype in breast cancer

BRCAness breast tumors represent a group of sporadic tumors characterized by a reduction in BRCA1 gene expression. As BRCA1 is involved in double-strand breaks (DSBs) repair, dysfunctional BRCA pathway could make a tumor sensitive to DNA damaging drugs (e.g., platinum agents). Thus, accurately ident...

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Udgivet i:Breast Cancer Res Treat
Main Authors: Branham, M. T., Campoy, E., Laurito, S., Branham, R., Urrutia, G., Orozco, J., Gago, F., Urrutia, R., Roqué, M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6036618/
https://ncbi.nlm.nih.gov/pubmed/26610810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-015-3648-0
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