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Formation of the Intrathymic Dendritic Cell Pool Requires CCL21-Mediated Recruitment of CCR7(+) Progenitors to the Thymus
During αβ T cell development in the thymus, migration of newly selected CD4(+) and CD8(+) thymocytes into medullary areas enables tolerance mechanisms to purge the newly selected αβ TCR repertoire of autoreactive specificities. Thymic dendritic cells (DC) play key roles in this process and consist o...
Gespeichert in:
| Veröffentlicht in: | J Immunol |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
AAI
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6036229/ https://ncbi.nlm.nih.gov/pubmed/29784760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800348 |
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