Formation of the Intrathymic Dendritic Cell Pool Requires CCL21-Mediated Recruitment of CCR7(+) Progenitors to the Thymus

During αβ T cell development in the thymus, migration of newly selected CD4(+) and CD8(+) thymocytes into medullary areas enables tolerance mechanisms to purge the newly selected αβ TCR repertoire of autoreactive specificities. Thymic dendritic cells (DC) play key roles in this process and consist o...

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Vydáno v:J Immunol
Hlavní autoři: Cosway, Emilie J., Ohigashi, Izumi, Schauble, Karin, Parnell, Sonia M., Jenkinson, William E., Luther, Sanjiv, Takahama, Yousuke, Anderson, Graham
Médium: Artigo
Jazyk:Inglês
Vydáno: AAI 2018
Témata:
Immune System Development
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6036229/
https://ncbi.nlm.nih.gov/pubmed/29784760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800348
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