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MgATP hydrolysis destabilizes the interaction between subunit H and yeast V(1)-ATPase, highlighting H's role in V-ATPase regulation by reversible disassembly

Vacuolar H(+)-ATPases (V-ATPases; V(1)V(o)-ATPases) are rotary-motor proton pumps that acidify intracellular compartments and, in some tissues, the extracellular space. V-ATPase is regulated by reversible disassembly into autoinhibited V(1)-ATPase and V(o) proton channel sectors. An important player...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Sharma, Stuti, Oot, Rebecca A., Wilkens, Stephan
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6036194/
https://ncbi.nlm.nih.gov/pubmed/29754144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002951
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