Targeting HOX-PBX interactions causes death in oral potentially malignant and squamous carcinoma cells but not normal oral keratinocytes

BACKGROUND: High HOX gene expression has been described in many cancers, including oral squamous cell carcinoma and the functional roles of these genes are gradually being understood. The pattern of overexpression suggests that inhibition may be useful therapeutically. Inhibition of HOX protein bind...

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Bibliographic Details
Published in:BMC Cancer
Main Authors: Platais, Christopher, Radhakrishnan, Raghu, Ebensberger, Sven Niklander, Morgan, Richard, Lambert, Daniel W., Hunter, Keith D.
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035449/
https://ncbi.nlm.nih.gov/pubmed/29980182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4622-0
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