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Targeting HOX-PBX interactions causes death in oral potentially malignant and squamous carcinoma cells but not normal oral keratinocytes

BACKGROUND: High HOX gene expression has been described in many cancers, including oral squamous cell carcinoma and the functional roles of these genes are gradually being understood. The pattern of overexpression suggests that inhibition may be useful therapeutically. Inhibition of HOX protein bind...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Platais, Christopher, Radhakrishnan, Raghu, Ebensberger, Sven Niklander, Morgan, Richard, Lambert, Daniel W., Hunter, Keith D.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035449/
https://ncbi.nlm.nih.gov/pubmed/29980182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4622-0
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