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Targeting HOX-PBX interactions causes death in oral potentially malignant and squamous carcinoma cells but not normal oral keratinocytes

BACKGROUND: High HOX gene expression has been described in many cancers, including oral squamous cell carcinoma and the functional roles of these genes are gradually being understood. The pattern of overexpression suggests that inhibition may be useful therapeutically. Inhibition of HOX protein bind...

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Bibliografske podrobnosti
izdano v:BMC Cancer
Main Authors: Platais, Christopher, Radhakrishnan, Raghu, Ebensberger, Sven Niklander, Morgan, Richard, Lambert, Daniel W., Hunter, Keith D.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035449/
https://ncbi.nlm.nih.gov/pubmed/29980182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4622-0
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