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Control of triple-negative breast cancer using ex vivo self-enriched, costimulated NKG2D CAR T cells

BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive disease that currently lacks effective targeted therapy. NKG2D ligands (NKG2DLs) are expressed on various tumor types and immunosuppressive cells within tumor microenvironments, providing suitable targets for cancer therapy. METHODS:...

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Pubblicato in:J Hematol Oncol
Autori principali: Han, Yali, Xie, Wei, Song, De-Gang, Powell, Daniel J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035420/
https://ncbi.nlm.nih.gov/pubmed/29980239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-018-0635-z
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