Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa

Pseudomonas aeruginosa colonises the upper airway of cystic fibrosis (CF) patients, providing a reservoir of host-adapted genotypes that subsequently establish chronic lung infection. We previously experimentally-evolved P. aeruginosa in a murine model of respiratory tract infection and observed ear...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Bricio-Moreno, Laura, Sheridan, Victoria H., Goodhead, Ian, Armstrong, Stuart, Wong, Janet K.L., Waters, Elaine M., Sarsby, Joscelyn, Panagiotou, Stavros, Dunn, James, Chakraborty, Adrita, Fang, Yongliang, Griswold, Karl E., Winstanley, Craig, Fothergill, Joanne L., Kadioglu, Aras, Neill, Daniel R.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035264/
https://ncbi.nlm.nih.gov/pubmed/29980663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04996-x
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