Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa

Pseudomonas aeruginosa colonises the upper airway of cystic fibrosis (CF) patients, providing a reservoir of host-adapted genotypes that subsequently establish chronic lung infection. We previously experimentally-evolved P. aeruginosa in a murine model of respiratory tract infection and observed ear...

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Publicat a:Nat Commun
Autors principals: Bricio-Moreno, Laura, Sheridan, Victoria H., Goodhead, Ian, Armstrong, Stuart, Wong, Janet K.L., Waters, Elaine M., Sarsby, Joscelyn, Panagiotou, Stavros, Dunn, James, Chakraborty, Adrita, Fang, Yongliang, Griswold, Karl E., Winstanley, Craig, Fothergill, Joanne L., Kadioglu, Aras, Neill, Daniel R.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035264/
https://ncbi.nlm.nih.gov/pubmed/29980663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04996-x
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