GSK3β-mediated Ser156 phosphorylation modulates a BH3-like domain in BCL2L12 during TMZ-induced apoptosis and autophagy in glioma cells

BH3 domains, classified initially as BCL2 homology domains, participate in both apoptosis and autophagy. Beclin-1 contains a BH3 domain, which is required for binding to antiapoptotic BCL2 homologs and BCL2-mediated inhibition of autophagy. BCL2-like 12 (BCL2L12) also harbors a BH3-like domain, whic...

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Vydáno v:Int J Mol Med
Hlavní autoři: Chu, Cheng-Wei, Yang, Ming-Chang, Chou, Chia-Hua, Huang, Wen-Sheng, Hsiao, Bo-Xiu, Wang, Yeng-Tseng, Chiou, Shean-Jaw, Loh, Joon-Khim, Hong, Yi-Ren
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034918/
https://ncbi.nlm.nih.gov/pubmed/29749471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2018.3672
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