The Structural Evolution of β-Secretase Inhibitors: A Focus on the Development of Small-Molecule Inhibitors

Effective treatment of Alzheimer’s disease (AD) remains a critical unmet need in medicine. The lack of useful treatment for AD led to an intense search for novel therapies based on the amyloid hypothesis, which states that amyloid β-42 (Aβ42) plays an early and crucial role in all cases of AD. β-Sec...

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Библиографические подробности
Опубликовано в: :Curr Top Med Chem
Главные авторы: Butini, Stefania, Brogi, Simone, Novellino, Ettore, Campiani, Giuseppe, Ghosh, Arun K., Brindisi, Margherita, Gemma, Sandra
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034716/
https://ncbi.nlm.nih.gov/pubmed/23931442
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