Transfer of gene-corrected T cells corrects humoral and cytotoxic defects in patients with X-linked lymphoproliferative disease

BACKGROUND: X-linked lymphoproliferative disease 1 arises from mutations in the SH2D1A gene encoding SLAM-associated protein (SAP), an adaptor protein expressed in T, natural killer (NK), and NKT cells. Defects lead to abnormalities of T-cell and NK cell cytotoxicity and T cell–dependent humoral fun...

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Veröffentlicht in:J Allergy Clin Immunol
Hauptverfasser: Panchal, Neelam, Houghton, Ben, Diez, Begona, Ghosh, Sujal, Ricciardelli, Ida, Thrasher, Adrian J., Gaspar, H. Bobby, Booth, Claire
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mosby 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034012/
https://ncbi.nlm.nih.gov/pubmed/29705247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2018.02.053
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