XRK3F2 Inhibition of p62-ZZ Domain Signaling Rescues Myeloma-Induced GFI1-Driven Epigenetic Repression of the Runx2 Gene in Pre-osteoblasts to Overcome Differentiation Suppression

Multiple myeloma bone disease (MMBD) is characterized by non-healing lytic bone lesions that persist even after a patient has achieved a hematologic remission. We previously reported that p62 (sequestosome-1) in bone marrow stromal cells (BMSC) is critical for the formation of MM-induced signaling c...

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Bibliographische Detailangaben
Veröffentlicht in:Front Endocrinol (Lausanne)
Hauptverfasser: Adamik, Juraj, Silbermann, Rebecca, Marino, Silvia, Sun, Quanhong, Anderson, Judith L., Zhou, Dan, Xie, Xiang-Qun, Roodman, G. David, Galson, Deborah L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Endocrinology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033965/
https://ncbi.nlm.nih.gov/pubmed/30008697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2018.00344
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