Hypoxia promotes breast cancer cell invasion through HIF-1α-mediated up-regulation of the invadopodial actin bundling protein CSRP2

Hypoxia is a common feature of solid tumours that promotes invasion and metastatic dissemination. Invadopodia are actin-rich membrane protrusions that direct extracellular matrix proteolysis and facilitate tumour cell invasion. Here, we show that CSRP2, an invadopodial actin bundling protein, is upr...

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Pubblicato in:Sci Rep
Autori principali: Hoffmann, Céline, Mao, Xianqing, Brown-Clay, Joshua, Moreau, Flora, Al Absi, Antoun, Wurzer, Hannah, Sousa, Barbara, Schmitt, Fernando, Berchem, Guy, Janji, Bassam, Thomas, Clément
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033879/
https://ncbi.nlm.nih.gov/pubmed/29976963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28637-x
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