Thymoquinone challenges UHRF1 to commit auto-ubiquitination: a key event for apoptosis induction in cancer cells

Down-regulation of UHRF1 (Ubiquitin-like containing PHD and Ring Finger 1) in Jurkat cells, induced by natural anticancer compounds such as thymoquinone, allows re-expression of tumor suppressor genes such as p73 and p16(INK4A). In order to decipher the mechanisms of UHRF1 down-regulation, we invest...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Ibrahim, Abdulkhaleg, Alhosin, Mahmoud, Papin, Christophe, Ouararhni, Khalid, Omran, Ziad, Zamzami, Mazin A., Al-Malki, Abdulrahman Labeed, Choudhry, Hani, Mély, Yves, Hamiche, Ali, Mousli, Marc, Bronner, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033341/
https://ncbi.nlm.nih.gov/pubmed/29983883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25583
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