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An unmutated IgM response to the Vi Polysaccharide of Salmonella Typhi contributes to protective immunity in a murine model of Typhoid
T cell-dependent B cell responses typically develop in germinal centers. Antibodies generated during such responses are isotype-switched and high-affinity to the antigen due to somatic hypermutation of antibody genes. B cell responses to purified polysaccharides are T cell-independent, do not result...
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| Udgivet i: | J Immunol |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6033073/ https://ncbi.nlm.nih.gov/pubmed/29743315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701348 |
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