TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds’ pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development

AIM: Thermoregulatory side effects hinder the development of transient receptor potential vanilloid‐1 (TRPV1) antagonists as new painkillers. While many antagonists cause hyperthermia, a well‐studied effect, some cause hypothermia. The mechanisms of this hypothermia are unknown and were studied here...

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Detalhes bibliográficos
Publicado no:Acta Physiol (Oxf)
Main Authors: Garami, A., Pakai, E., McDonald, H. A., Reilly, R. M., Gomtsyan, A., Corrigan, J. J., Pinter, E., Zhu, D. X. D., Lehto, S. G., Gavva, N. R., Kym, P. R., Romanovsky, A. A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Metobolism and Nutritional Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6032921/
https://ncbi.nlm.nih.gov/pubmed/29352512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/apha.13038
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