Mbd2 enables tumourigenesis within the intestine while preventing tumour‐promoting inflammation

Epigenetic regulation plays a key role in the link between inflammation and cancer. Here we examine Mbd2, which mediates epigenetic transcriptional silencing by binding to methylated DNA. In separate studies the Mbd2 (−/−) mouse has been shown (1) to be resistant to intestinal tumourigenesis and (2)...

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Vydáno v:J Pathol
Hlavní autoři: May, Stephanie, Owen, Heather, Phesse, Toby J, Greenow, Kirsty R, Jones, Gareth‐Rhys, Blackwood, Adam, Cook, Peter C, Towers, Christopher, Gallimore, Awen M, Williams, Geraint T, Stürzl, Michael, Britzen‐Laurent, Nathalie, Sansom, Owen J, MacDonald, Andrew S, Bird, Adrian P, Clarke, Alan R, Parry, Lee
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Ltd 2018
Témata:
Original Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6032908/
https://ncbi.nlm.nih.gov/pubmed/29603746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5074
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