Mbd2 enables tumourigenesis within the intestine while preventing tumour‐promoting inflammation

Epigenetic regulation plays a key role in the link between inflammation and cancer. Here we examine Mbd2, which mediates epigenetic transcriptional silencing by binding to methylated DNA. In separate studies the Mbd2 (−/−) mouse has been shown (1) to be resistant to intestinal tumourigenesis and (2)...

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Veröffentlicht in:J Pathol
Hauptverfasser: May, Stephanie, Owen, Heather, Phesse, Toby J, Greenow, Kirsty R, Jones, Gareth‐Rhys, Blackwood, Adam, Cook, Peter C, Towers, Christopher, Gallimore, Awen M, Williams, Geraint T, Stürzl, Michael, Britzen‐Laurent, Nathalie, Sansom, Owen J, MacDonald, Andrew S, Bird, Adrian P, Clarke, Alan R, Parry, Lee
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Ltd 2018
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Original Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6032908/
https://ncbi.nlm.nih.gov/pubmed/29603746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5074
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