Radioprotective Effects of Dermatan Sulfate in a Preclinical Model of Oral Mucositis—Targeting Inflammation, Hypoxia and Junction Proteins without Stimulating Proliferation

Oral mucositis is the most frequently occurring early side effect of head-and-neck cancer radiotherapy. Systemic dermatan sulfate (DS) treatment revealed a significant radioprotective potential in a preclinical model of oral mucositis. This study was initiated to elucidate the mechanistic effects of...

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Udgivet i:Int J Mol Sci
Main Authors: Gruber, Sylvia, Arnold, Marlene, Cini, Nilsu, Gernedl, Victoria, Hetzendorfer, Sabine, Kowald, Lisa-Marie, Kuess, Peter, Mayer, Julia, Morava, Susanne, Pfaffinger, Stephanie, Rohorzka, Andreas, Dörr, Wolfgang
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6032103/
https://ncbi.nlm.nih.gov/pubmed/29882770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19061684
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