A Selective Extracellular Matrix Proteomics Approach Identifies Fibronectin Proteolysis by A Disintegrin-like and Metalloprotease Domain with Thrombospondin Type 1 Motifs (ADAMTS16) and Its Impact on Spheroid Morphogenesis

Secreted and cell-surface proteases are major mediators of extracellular matrix (ECM) turnover, but their mechanisms and regulatory impact are poorly understood. We developed a mass spectrometry approach using a cell-free ECM produced in vitro to identify fibronectin (FN) as a novel substrate of the...

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Publicado en:Mol Cell Proteomics
Autores principales: Schnellmann, Rahel, Sack, Ragna, Hess, Daniel, Annis, Douglas S., Mosher, Deane F., Apte, Suneel S., Chiquet-Ehrismann, Ruth
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2018
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030725/
https://ncbi.nlm.nih.gov/pubmed/29669734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA118.000676
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