Cyclosporin A Impairs the Secretion and Activity of ADAMTS13 (A Disintegrin and Metalloprotease with Thrombospondin Type 1 Repeat)

The protease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeat) cleaves multimers of von Willebrand factor, thus regulating platelet aggregation. ADAMTS13 deficiency leads to the fatal disorder thrombotic thrombocytopenic purpura (TTP). It has been observed that cyclospor...

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Autors principals: Hershko, Klilah, Simhadri, Vijaya L., Blaisdell, Adam, Hunt, Ryan C., Newell, Jordan, Tseng, Sandra C., Hershko, Alon Y., Choi, Jae Won, Sauna, Zuben E., Wu, Andrew, Bram, Richard J., Komar, Anton A., Kimchi-Sarfaty, Chava
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531750/
https://ncbi.nlm.nih.gov/pubmed/23144461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.383968
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