Cyclosporin A Impairs the Secretion and Activity of ADAMTS13 (A Disintegrin and Metalloprotease with Thrombospondin Type 1 Repeat)

The protease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeat) cleaves multimers of von Willebrand factor, thus regulating platelet aggregation. ADAMTS13 deficiency leads to the fatal disorder thrombotic thrombocytopenic purpura (TTP). It has been observed that cyclospor...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Hershko, Klilah, Simhadri, Vijaya L., Blaisdell, Adam, Hunt, Ryan C., Newell, Jordan, Tseng, Sandra C., Hershko, Alon Y., Choi, Jae Won, Sauna, Zuben E., Wu, Andrew, Bram, Richard J., Komar, Anton A., Kimchi-Sarfaty, Chava
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2012
विषय:
Molecular Bases of Disease
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531750/
https://ncbi.nlm.nih.gov/pubmed/23144461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.383968
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