Viral Entry Properties Required for Fitness in Humans Are Lost through Rapid Genomic Change during Viral Isolation

Human parainfluenza viruses cause a large burden of human respiratory illness. While much research relies upon viruses grown in cultured immortalized cells, human parainfluenza virus 3 (HPIV-3) evolves in culture. Cultured viruses differ in their properties compared to clinical strains. We present a...

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Bibliographic Details
Published in:mBio
Main Authors: Iketani, Sho, Shean, Ryan C., Ferren, Marion, Makhsous, Negar, Aquino, Dolly B., des Georges, Amedee, Rima, Bert, Mathieu, Cyrille, Porotto, Matteo, Moscona, Anne, Greninger, Alexander L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030562/
https://ncbi.nlm.nih.gov/pubmed/29970463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00898-18
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