Single-Cell Approach to Influenza-Specific CD8(+) T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus Infection

CD8(+) T cells recognizing antigenic peptides derived from conserved internal viral proteins confer broad protection against distinct influenza viruses. As memory CD8(+) T cells change throughout the human lifetime and across tissue compartments, we investigated how T cell receptor (TCR) composition...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Sant, Sneha, Grzelak, Ludivine, Wang, Zhongfang, Pizzolla, Angela, Koutsakos, Marios, Crowe, Jane, Loudovaris, Thomas, Mannering, Stuart I., Westall, Glen P., Wakim, Linda M., Rossjohn, Jamie, Gras, Stephanie, Richards, Michael, Xu, Jianqing, Thomas, Paul G., Loh, Liyen, Nguyen, Thi H. O., Kedzierska, Katherine
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030351/
https://ncbi.nlm.nih.gov/pubmed/29997621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01453
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