Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA

Mouse toll-like receptor 9 (TLR9) is an endosomal sensor for single-stranded DNA. TLR9 is transported from the endoplasmic reticulum to endolysosomes by a multiple transmembrane protein Unc93 homolog B1, and proteolytically cleaved at its ectodomain. The structure of TLR9 and its biochemical analyse...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Fukui, Ryutaro, Yamamoto, Chikako, Matsumoto, Fumi, Onji, Masahiro, Shibata, Takuma, Murakami, Yusuke, Kanno, Atsuo, Hayashi, Takuto, Tanimura, Natsuko, Yoshida, Nobuaki, Miyake, Kensuke
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030252/
https://ncbi.nlm.nih.gov/pubmed/29997629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01491
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