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BRAP-2 promotes DNA damage induced germline apoptosis in C. elegans through the regulation of SKN-1 and AKT-1

As part of the DNA damage response (DDR) network, the tumour suppressor Breast cancer susceptibility gene 1 (BRCA1) is activated to facilitate DNA repair, transcription and cell cycle control. BRC-1, the Caenorhabditis elegans ortholog of BRCA1, has conserved function in DNA double strand break repa...

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Detalles Bibliográficos
Publicado en:Cell Death Differ
Main Authors: D’Amora, Dayana R., Hu, Queenie, Pizzardi, Monica, Kubiseski, Terrance J.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030105/
https://ncbi.nlm.nih.gov/pubmed/29358669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-017-0038-7
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