Kynurenic acid, an IDO metabolite, controls TSG-6-mediated immunosuppression of human mesenchymal stem cells

Mesenchymal stem cells (MSCs) have been demonstrated to be anti-inflammatory against various immune disorders through several factors, including indoleamine 2,3-dioxygenase (IDO) and TNF-stimulated gene 6 (TSG-6). However, little is known about the necessity for both of these key immunosuppressive f...

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Veröffentlicht in:Cell Death Differ
Hauptverfasser: Wang, Guan, Cao, Kai, Liu, Keli, Xue, Yueqing, Roberts, Arthur I., Li, Fengying, Han, Yanyan, Rabson, Arnold B., Wang, Ying, Shi, Yufang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030103/
https://ncbi.nlm.nih.gov/pubmed/29238069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-017-0006-2
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