Motor-like DNA motion due to an ATP-hydrolyzing protein under nanoconfinement

We report that long double-stranded DNA confined to quasi-1D nanochannels undergoes superdiffusive motion under the action of the enzyme T4 DNA ligase in the presence of necessary co-factors. Inside the confined environment of the nanochannel, double-stranded DNA molecules stretch out due to self-av...

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Udgivet i:Sci Rep
Main Authors: Roushan, Maedeh, Azad, Zubair, Movahed, Saeid, Ray, Paul D., Livshits, Gideon I., Lim, Shuang Fang, Weninger, Keith R., Riehn, Robert
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030079/
https://ncbi.nlm.nih.gov/pubmed/29968756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28278-0
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