PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects

BACKGROUND: Inflammation is associated with major depressive disorder (MDD). Translocator protein 18 kDa (TSPO), a putative biomarker of neuroinflammation, is quantified using positron emission tomography (PET) and (11)C-PBR28, a TSPO tracer. We sought to (1) investigate TSPO binding in MDD subjects...

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Publicat a:EJNMMI Res
Autors principals: Richards, Erica M., Zanotti-Fregonara, Paolo, Fujita, Masahiro, Newman, Laura, Farmer, Cristan, Ballard, Elizabeth D., Machado-Vieira, Rodrigo, Yuan, Peixiong, Niciu, Mark J., Lyoo, Chul Hyoung, Henter, Ioline D., Salvadore, Giacomo, Drevets, Wayne C., Kolb, Hartmuth, Innis, Robert B., Zarate Jr, Carlos A.
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2018
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029989/
https://ncbi.nlm.nih.gov/pubmed/29971587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-018-0401-9
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