Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis

Matrix stiffening with downstream activation of mechanosensitive pathways is strongly implicated in progressive fibrosis; however, pathologic changes in extracellular matrix (ECM) that initiate mechano-homeostasis dysregulation are not defined in human disease. By integrated multiscale biomechanical...

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Bibliographic Details
Published in:eLife
Main Authors: Jones, Mark G, Andriotis, Orestis G, Roberts, James JW, Lunn, Kerry, Tear, Victoria J, Cao, Lucy, Ask, Kjetil, Smart, David E, Bonfanti, Alessandra, Johnson, Peter, Alzetani, Aiman, Conforti, Franco, Doherty, Regan, Lai, Chester Y, Johnson, Benjamin, Bourdakos, Konstantinos N, Fletcher, Sophie V, Marshall, Ben G, Jogai, Sanjay, Brereton, Christopher J, Chee, Serena J, Ottensmeier, Christian H, Sime, Patricia, Gauldie, Jack, Kolb, Martin, Mahajan, Sumeet, Fabre, Aurelie, Bhaskar, Atul, Jarolimek, Wolfgang, Richeldi, Luca, O'Reilly, Katherine MA, Monk, Phillip D, Thurner, Philipp J, Davies, Donna E
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2018
Subjects:
Human Biology and Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029847/
https://ncbi.nlm.nih.gov/pubmed/29966587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.36354
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