Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis

Matrix stiffening with downstream activation of mechanosensitive pathways is strongly implicated in progressive fibrosis; however, pathologic changes in extracellular matrix (ECM) that initiate mechano-homeostasis dysregulation are not defined in human disease. By integrated multiscale biomechanical...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Jones, Mark G, Andriotis, Orestis G, Roberts, James JW, Lunn, Kerry, Tear, Victoria J, Cao, Lucy, Ask, Kjetil, Smart, David E, Bonfanti, Alessandra, Johnson, Peter, Alzetani, Aiman, Conforti, Franco, Doherty, Regan, Lai, Chester Y, Johnson, Benjamin, Bourdakos, Konstantinos N, Fletcher, Sophie V, Marshall, Ben G, Jogai, Sanjay, Brereton, Christopher J, Chee, Serena J, Ottensmeier, Christian H, Sime, Patricia, Gauldie, Jack, Kolb, Martin, Mahajan, Sumeet, Fabre, Aurelie, Bhaskar, Atul, Jarolimek, Wolfgang, Richeldi, Luca, O'Reilly, Katherine MA, Monk, Phillip D, Thurner, Philipp J, Davies, Donna E
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Human Biology and Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029847/
https://ncbi.nlm.nih.gov/pubmed/29966587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.36354
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