Activation of Th2 cells downregulates CRTh2 through an NFAT1 mediated mechanism

CRTh2 (encoded by PTGDR2) is a G-protein coupled receptor expressed by Th2 cells as well as eosinophils, basophils and innate lymphoid cells (ILC)2s. Activation of CRTh2, by its ligand prostaglandin (PG)D(2), mediates production of type 2 cytokines (IL-4, IL-5 and IL-13), chemotaxis and inhibition o...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: MacLean Scott, Emily, Solomon, Lauren A., Davidson, Courtney, Storie, Jessica, Palikhe, Nami Shrestha, Cameron, Lisa
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029763/
https://ncbi.nlm.nih.gov/pubmed/29969451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0199156
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