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IL-1 Receptor Antagonist Reduced Chemical-Induced Keratinocyte Apoptosis through Antagonism to IL-1α/IL-1β

Extracellular interleukin 1 alpha (IL-1α) released from keratinocytes is one of the endpoints for in vitro assessments of skin irritancy. Although cells dying via primary skin irritation undergo apoptosis as well as necrosis, IL-1α is not released in apoptotic cells. On the other hand, active secret...

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Detalhes bibliográficos
Publicado no:Biomol Ther (Seoul)
Main Authors: Lee, Hyejin, Cheong, Kyung Ah, Kim, Ji-Young, Kim, Nan-Hyung, Noh, Minsoo, Lee, Ai-Young
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Society of Applied Pharmacology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029682/
https://ncbi.nlm.nih.gov/pubmed/29310426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2017.167
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