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Increased intracellular iron in mouse primary hepatocytes in vitro causes activation of the Akt pathway but decreases its response to insulin

BACKGROUND: An iron-overloaded state has been reported to be associated with insulin resistance. On the other hand, conditions such as classical hemochromatosis (where iron overload occurs primarily in the liver) have been reported to be associated with increased insulin sensitivity. The reasons for...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Varghese, Joe, James, Jithu, Vaulont, Sophie, Mckie, Andrew, Jacob, Molly
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029669/
https://ncbi.nlm.nih.gov/pubmed/29859963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2018.05.022
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