Novel oncogene COPS3 interacts with Beclin1 and Raf-1 to regulate metastasis of osteosarcoma through autophagy

BACKGROUND: Expression of COP9 signalosome subunit 3 (COPS3), an oncogene overexpressed in osteosarcoma, has been demonstrated to be significantly correlated with tumor metastasis. However, the underlying mechanism by which COPS3 promotes metastasis of osteosarcoma and its role in autophagy remain u...

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Bibliografiske detaljer
Udgivet i:J Exp Clin Cancer Res
Main Authors: Zhang, Fan, Yan, Taiqiang, Guo, Wei, Sun, Kunkun, Wang, Shidong, Bao, Xing, Liu, Kuisheng, Zheng, Bingxin, Zhang, Hongliang, Ren, Tingting
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029018/
https://ncbi.nlm.nih.gov/pubmed/29970115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0791-6
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