Apatinib promotes autophagy and apoptosis through VEGFR2/STAT3/BCL-2 signaling in osteosarcoma

The cure rate of osteosarcoma has not improved in the past 30 years. The search for new treatments and drugs is urgently needed. Apatinib is a high selectivity inhibitor of vascular endothelial growth factor receptor-2 (VEGFR2) tyrosine kinase, exerting promising antitumoral effect in various tumors...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Death Dis
Main Authors: Liu, Kuisheng, Ren, Tingting, Huang, Yi, Sun, Kunkun, Bao, Xing, Wang, Shidong, Zheng, Bingxin, Guo, Wei
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596600/
https://ncbi.nlm.nih.gov/pubmed/28837148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.422
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