Stability of an aggregation-prone partially folded state of human profilin-1 correlates with aggregation propensity

A set of missense mutations in the gene encoding profilin-1 has been linked to the onset of familial forms of ALS (fALS), also known as Lou Gehrig's disease. The pathogenic potential of these mutations is linked to the formation of intracellular inclusions of the mutant proteins and correlates...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Del Poggetto, Edoardo, Toto, Angelo, Aloise, Chiara, Di Piro, Francesco, Gori, Ludovica, Malatesta, Francesco, Gianni, Stefano, Chiti, Fabrizio, Bemporad, Francesco
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028969/
https://ncbi.nlm.nih.gov/pubmed/29760185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002087
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