Stability of an aggregation-prone partially folded state of human profilin-1 correlates with aggregation propensity

A set of missense mutations in the gene encoding profilin-1 has been linked to the onset of familial forms of ALS (fALS), also known as Lou Gehrig's disease. The pathogenic potential of these mutations is linked to the formation of intracellular inclusions of the mutant proteins and correlates...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Del Poggetto, Edoardo, Toto, Angelo, Aloise, Chiara, Di Piro, Francesco, Gori, Ludovica, Malatesta, Francesco, Gianni, Stefano, Chiti, Fabrizio, Bemporad, Francesco
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2018
Ämnen:
Protein Structure and Folding
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028969/
https://ncbi.nlm.nih.gov/pubmed/29760185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002087
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