Reduction of Protein Kinase A-mediated Phosphorylation of ATXN1-S776 in Purkinje Cells Delays Onset of Ataxia in a SCA1 Mouse Model

Spinocerebellar ataxia type 1 (SCA1) is a polyglutamine (polyQ) repeat neurodegenerative disease in which a primary site of pathogenesis are cerebellar Purkinje cells. In addition to polyQ expansion of ataxin-1 protein (ATXN1), phosphorylation of ATXN1 at the serine 776 residue (ATXN1-pS776) plays a...

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Publicado no:Neurobiol Dis
Main Authors: Pérez Ortiz, Judit M., Mollema, Nissa, Toker, Nicholas, Adamski, Carolyn J., O’Callaghan, Brennon, Duvick, Lisa, Friedrich, Jillian, Walters, Michael A., Strasser, Jessica, Hawkinson, Jon E., Zoghbi, Huda Y., Henzler, Christine, Orr, Harry T., Lagalwar, Sarita
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028938/
https://ncbi.nlm.nih.gov/pubmed/29758256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.05.002
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