Tetrodotoxin-sensitive Na(v)s contribute to early and delayed afterdepolarizations in long QT arrhythmia models

Recent evidence suggests that neuronal Na(+) channels (nNa(v)s) contribute to catecholamine-promoted delayed afterdepolarizations (DADs) and catecholaminergic polymorphic ventricular tachycardia (CPVT). The newly identified overlap between CPVT and long QT (LQT) phenotypes has stoked interest in the...

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Detalhes bibliográficos
Publicado no:J Gen Physiol
Main Authors: Koleske, Megan, Bonilla, Ingrid, Thomas, Justin, Zaman, Naveed, Baine, Stephen, Knollmann, Bjorn C., Veeraraghavan, Rengasayee, Györke, Sándor, Radwański, Przemysław B.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028491/
https://ncbi.nlm.nih.gov/pubmed/29793933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201711909
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