Novel Mutations in pncA Gene of Pyrazinamide Resistant Clinical Isolates of Mycobacterium tuberculosis

In clinical isolates of Mycobacterium tuberculosis (MTB), resistance to pyrazinamide occurs by mutations in any positions of the pncA gene (NC_000962.3) especially in nucleotides 359 and 374. In this study we examined the pncA gene sequence in clinical isolates of MTB. Genomic DNA of 33 clinical iso...

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Veröffentlicht in:Sci Pharm
Hauptverfasser: Kahbazi, Manijeh, Sarmadian, Hossein, Ahmadi, Azam, Didgar, Farshideh, Sadrnia, Maryam, Poolad, Toktam, Arjomandzadegan, Mohammad
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027673/
https://ncbi.nlm.nih.gov/pubmed/29659533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/scipharm86020015
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