Dengue Virus Induces Increased Activity of the Complement Alternative Pathway in Infected Cells

Severe dengue virus (DENV) infection is associated with overactivity of the complement alternative pathway (AP) in patient studies. Here, the molecular changes in components of the AP during DENV infection in vitro were investigated. mRNA for factor H (FH), a major negative regulator of the AP, was...

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Udgivet i:J Virol
Main Authors: Cabezas, Sheila, Bracho, Gustavo, Aloia, Amanda L., Adamson, Penelope J., Bonder, Claudine S., Smith, Justine R., Gordon, David L., Carr, Jillian M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026742/
https://ncbi.nlm.nih.gov/pubmed/29743365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00633-18
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