Dengue Virus Induces Increased Activity of the Complement Alternative Pathway in Infected Cells

Severe dengue virus (DENV) infection is associated with overactivity of the complement alternative pathway (AP) in patient studies. Here, the molecular changes in components of the AP during DENV infection in vitro were investigated. mRNA for factor H (FH), a major negative regulator of the AP, was...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Cabezas, Sheila, Bracho, Gustavo, Aloia, Amanda L., Adamson, Penelope J., Bonder, Claudine S., Smith, Justine R., Gordon, David L., Carr, Jillian M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026742/
https://ncbi.nlm.nih.gov/pubmed/29743365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00633-18
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