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Neopterin/7,8-dihydroneopterin is elevated in Duchenne muscular dystrophy patients and protects mdx skeletal muscle function

Macrophage infiltration is a hallmark of dystrophin-deficient muscle. We tested the hypothesis that Duchenne muscular dystrophy (DMD) patients would have elevated levels of the macrophage synthesized pterins, neopterin and 7,8-dihydroneopterin compared to unaffected age-matched controls. Urinary neo...

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Detalhes bibliográficos
Publicado no:Exp Physiol
Main Authors: Lindsay, Angus, Schmiechen, Alexandra, Chamberlain, Christopher M., Ervasti, James M., Lowe, Dawn A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026059/
https://ncbi.nlm.nih.gov/pubmed/29791760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/EP087031
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